Description
Product Characteristics:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Kr_ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ANKZF1 (ankyrin repeat and zinc finger domain containing 1), also known as ZNF744, is 726 amino acids in length and lacks a KRAB domain but contains one C2H2-type zinc finger and two ANK repeats. The gene encoding ANKZF1 localizes to chromosome 2.
Subcellular location: Cytoplasm
Synonyms: Ankyrin repeat and zinc finger domain containing 1, Ankyrin repeat and zinc finger domain containing protein 1, ANKZF 1, ANKZF1 protein, FLJ10415, Zinc finger protein 744, ZNF744, ANKZ1_HUMAN.
Target Information: Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway (By similarity)